Investigating HLH

Diagnosing Hemophagocytic Lymphohistiocytosis (HLH)

Episode Summary

Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing hemophagocytic lymphohistiocytosis (HLH).

Episode Notes

Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing hemophagocytic lymphohistiocytosis (HLH). The discussion focuses on key considerations in HLH management, treatment goals, and clinical complexities involved in evaluating patients with HLH.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - Why HLH Diagnosis Can Be Challenging

4:59 - Why Early and Accurate HLH Diagnosis Matters

10:10 - HLH Diagnostic Criteria and Clinical Workup

25:31 - Genetic Testing and Functional Assays for HLH

37:26 - Biomarkers in HLH Diagnosis: Ferritin, sCD25, and CXCL9

43:00 - HLH Disease Mimics and Differential Diagnosis

54:00 - HLH Guidelines: Limitations and Clinical Judgment

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